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African bitter leaf (Vernonia amygdalina Delile) - a medicinal and nutritional wonder of family Asteraceae


Vernonia amygdalina Delile is an important plant species well-known for its medicinal as well as nutritional values. Various phytochemical studies proved that, the plant contains many bioactive compounds of different pharmacological properties, proteins, fats, fibres, amino acids, minerals, vitamins, carbohydrates, etc. Considerable disagreement prevails in the placement of this species under the genus Gymnanthemum Cass. instead of Vernonia Schreb. This paper thus reviews the scientific knowledge on its medicinal as well as nutritional values and future prospective.


Bioactive Compounds, Vernonia amygdalina, Leafy Vegetable, Medicinal.



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  1. ABOSI, A.O. AND B.H. RASORETA 2003. In-vivo anti-malarial activity of V. amygdalina Del. Brit. J. Biomed. Sc. 60(2):89–91.
  2. ADAMA, K.K., A.A. OBERAFO AND S. DIKA 2011. Bitterleaf as Local Substitute for Hops in the Nigerian Brewing Industry. Scholars Research Library 3(4): 388–397.
  3. ADEDAPO, A.A., O.J. AREMU, A.A. OYAGBEMI 2014. Anti-oxidant, Anti-inflammatory and Antinociceptive Properties of the Acetone Leaf Extract of Vernonia amygdalina in Some Laboratory Animals. Adv. Pharm. Bull. 4: 591–598.
  4. ADESANOYE, O.A. AND E.O. FAROMBI 2010. Hepatoprotective effects of Vernonia amygdalina (Asteraceae) in rats treated with carbon tetrachloride. Exp. Toxicol. Pathol. 62:197–206.
  5. ADETUNJI, C.O., O.O. OLANIYI AND A.T.J. OGUNKUNLE 2013. Bacterial Activity of Crude Extracts of Vernonia amygdalina on Clinical Isolates. J. Microbiol. Antimicrob. 5(6): 60–64.
  6. AGBOGIDI, O.M. AND M. AKPOMORINE 2013. Health and Nutritional Benefits of Bitterleaf (Vernonia amygdalina Del.). Int. J. Applied Pharmac. Sc. Biol. Sc. 2(3): 164–170.
  7. AGRAWALA, D.K., T.K. MANDAL, ROHIT SARDA AND SANJAY KHAMARI 2016 (2017). Med Plant Newsletter 9 (1 – 4): 17–18.
  8. AKAH, P.A., J.A. ALEMJI, O.A. SALAWU, T.C. OKOYE AND N.V. OFFIAH 2009. Effects of Vernonia amygdalina on Biochemical and Haematological Parameters in Diabetic Rats. Asian J. Med. Sc. 1(3): 108–113.
  9. AKAH, P.A. AND C.L. OKAFOR 1992. Blood sugar lowering effect of Vernonia amygdalina Del. in an experimental rabbit model. Phytotherapy Research 6: 171–173.
  10. AKINPELU, D.A. 1999. Antimicrobial Activity of Vernonia amygdalina leaves. Fitoterapia 70(4): 432– 434.
  11. AKINYELE, B.J., B.O. OLADEJO, A.I. AKINYEMI AND L.O. EZEM 2014. Comparative Study of the Antibacterial Effect of Mouth Washes and Vernonia amygdalina (Del.) on Some Tooth Decay Causing Bacteria. British Microbiology Research Journal 4(7): 749–758
  12. AKPASO, M.I., I.J. ATANGWHO, A. AKPANTAH, V.A. FISCHER, A.O. IGIRI AND P.E. EBONG 2011. Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic β-Cells of Streptozotocin-Induced Diabetic Rats. British Journal of Medicine & Medical Research 1(11): 24–34.
  13. ALABI, D.A., L.A. OYERO AND N.A. JIMOH AMUSA 2005. Fungitoxic and phytotoxic effect of Vernonia amygdalina Del., Bryophyllum pinnantus Kurz, Ocimum gratissimum (Closium) L and Eucalypta globules (Caliptos) Labill water extracts on cowpea and cowpea seedling pathogens in Ago-Iwoye, South Western Nigeria. World J. Agric. Sci. 1: 70–75.
  14. ALARA, O.R., N.H. ABDURAHMAN AND O.A. OLALERE 2020. Ethanolic extraction of flavonoids, phenolics and antioxidants from Vernonia amygdalina leaf using two-level factorial design. Journal of King Saud University - Science 32(1): 7–16.
  15. ANIBIJUWON, I.I., B.O. OLADEJO, D.O. ADETITUN AND O.M. KOLAWOLE 2012. Antimicrobial Activities of Vernonia amygdalina against Oral Microbes. Global J. Pharmacol. 6(3): 178–185.
  16. ANJULA PANDEY, K. PRADHEEP AND NEELAM SHARMA 2014. Potential introduced medicinal plant African bitter leaf (Vernonia amygdalina Delile) in India: botany, propagation and uses. Medicinal Plants 6(4): 272–276.
  17. ANKIT SANEJA, K.R. CHETAN SHARMA AND R.P. ANEJA 2010. Bitterleaf as Local Substitute for Hops in the Nigerian Brewing Industry. Pharmacia 2(2): 208–220.
  18. ASANTE, D.B., E. EFFAH-YEBOAH, P. BARNES, H.A. ABBAN, E.O. AMEYAW, J.N. BOAMPONG AND J.B. DADZIE 2016. Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study. J. Diabetes Res. 1–13.
  19. ATANGWHO, I.J., G.E. EGBUNG, M. AHMAD, M.F. YAM, M.Z. ASMAWI 2013. Antioxidant versus Anti-diabetic Properties of Leaves from Vernonia amygdalina Del. growing in Malaysia. Food Chem. 141(4): 3428–3434.
  20. ATANGWHO, I.J., K.B. YIN, M.I. UMAR, M. AHMAD AND M.Z. ASMAWI 2014. Vernonia amygdalina Simultaneously Suppresses Gluconeogenesis and Potentiates Glucose Oxidation via the Pentose Phosphate Pathway in Streptozotocin-Induced Diabetic Rats. BMC Complement Altern. Med. 14(1): 426.
  21. ATANGWHO, J., F.A. IME, E.E. GODWIN AND A.I. MARY 2011. Changes in some liver lipids of non-diabetic and diabetic rats following administration of combined extracts of Vernonia amygdalina and Azadirachta indica. Agric. Biol. J. N. Am. 2(7): 1096–1100.
  22. AUDU, S., A. TAIWO, A. OJUOLAPE, A. SANI, A. BUKOLA AND I. MOHAMMED 2012. A Study Review of Documented Phytochemistry of Vernonia Amygdalina (Family Asteraceae) as the Basis for Pharmacologic Activity of Plant Extract. J. Natural Sci. Res. 2: 1–9.
  23. AYOOLA, G., H. COKER, S. ADESEGUN, A. ADEPOJU-BELLO, K. OBAWEYA, E. EZENNIA AND T. ATANGBAYILA, T. 2008. Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern
  24. BHATTACHARJEE, B., P. LAKSHMINARASIMHAN, S.K. MUKHERJEE AND A. BHATTACHARJEE 2019. A conspectus of the Tribe Vernonieae (Asteraceae) in India. In: AGNIHOTRI, P AND J.S. KHURAIJAM (eds.), Angiosperm Systematics: Recent trends and emerging issues (Felicitation volume in honour of Dr. Tariq Husain). Bishen Singh Mahendra Pal Singh, Dehradun, pp. 107–123.
  25. BHATTACHARJEE, B., P. LAKSHMINARASIMHAN, A. BHATTACHARJEE, D.K. AGRAWALA AND M.K. PATHAK 2013. Vernonia amygdalina Delile (Asteraceae)- An African medicinal plant introduced in India. Zoo’s Print 28(5): 18–20.
  26. CHEN, Y.U., J.MA, F. WANG, J. HU, A. CUI & AL., 2013. Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells. Immunopharmacol Immunotoxicol 35(1):43–51.
  27. CIMANGA, R.K., L. TONA, K. MESIA, C.T. MUSUAMBA, T. DE BRUYNE, S. APERS, N. HERNAN, V.S. MIERT, L. PIETERS, J. TOTTE AND A.J. VLIETINK 2004. In vitro antiplasmodia acivity of extracts and fractions of seven medicinal plants used in the democratic republic of Congo. J. Ethnopharmacol. 93:27–32.
  28. DAS, D.K. AND C. SIVAPERUMAN 2021. Gymnanthemum amygdalinum (Delile) Sch. Bip. ex Walp (Asteraceae)-A new report to the flora of Andaman and Nicobar Islands, India. J. New Biol. Rep. 10 (1): 13–15.
  29. EDEOGA, H.O., A. GOMINA 2000. Nutritional values of some non-conventional leafy vegetables of Nigeria. J. Enon. Taxon. Bot. 24: 7–13.
  30. EGHAREVBA, C., E. OSAYEMWENRE, V. IMIEJE, J. AHOMAFOR, C. AKUNYULI, A. A. UDU-COSI, O. THEOPHILUS, O. JAMES, I. LI AND A. FALODUN 2014. Significance of Bitter Leaf (Vernonia amgdalina) In Tropical Diseases and Beyond: A Review. Malaria Chemotherapy Control and Elimination 3(1): 1–10.
  31. EJOH, A.R., A.N. TANGO, N.A. OJUIKWO AND C.M. MBOFUNG 2005. Effects of processing and preservation methods on vitamin C and total carotenoid leaves of some Vernonia species. African Journal of Food, Agriculture, Nutrition and Development 5(2):105–117.
  32. ERASTO, P., D.S. GRIERSON AND A.J. AFOLAYAN 2006. Bioactive Sesquiterpene Lactones from the Leaves of Vernonia amygdalina. J. Ethnopharmacol. 106: 117–120.
  33. ERASTO, P., D.S. GRIERSON AND A.J. AFOLAYAN 2007. Evaluation of Antioxidant Activity and the Fatty Acid Profile of the Leaves of Vernonia amygdalina Growing in South Africa. Food Chemistry 104: 636–642.
  34. EZEADILA, J.O., M.O. NWANDE, G.I. OGU, F.A. ANEKE AND J.O. EZEADILA 2015. Antibacterial Activity of Ethyl Acetate And n-Hexane Extracts of Vernonia amygdalina and Moringa oleifera Leaves on Staphylococcus aureus and Escherichia coli Isolated from Urine Samples. Pelagia Research Library 6(11): 23–28.
  35. FAROMBI, E.O. AND O. OWOEYE 2011. Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid. Int. J. Environ. Res. Public Health 8: 2533–2555.
  36. GRESHAM, L.J., J. ROSS AND E.B. IZEVBIGIE 2008. Vernonia amygdalina: Anticancer Activity, Authentication, and Adulteration Detection. Int. J. Environ. Res. Public Health 5(5): 342–348.
  37. HEE YOUNG, K., H. SEON PYO, H. DONG HOON AND K. JEONG HEE 2003. Apoptosis induction of Persicae Semen extract in human promyelocytic leukemia (HL 60) cells. Arch. Pharm. Res. 26(2):157–161.
  38. HOWARD, C.B., J. STEVENS, E.B. IZEVBIGIE, A. WALKER AND O. MCDANIEL 2003. Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent. Cell Mol. Biol. (Noisy-le-grand) 49:1057–1065.
  39. IBRAHIM, T.A., A. LOLA, F.O. ADETUYI AND JUDE-OJEI 2009. Assessment of the antibacterial activity of Vernonia amygdalina and Ocimum gratissimum leaves on selected food borne pathogens. J. Environ. Agric. and Food Chemistry 8(11): 1212–1218.
  40. IBRAHIM, G., E.M. ABDURAHMAN, H. IBRAHIM AND N.O. IBRAHIM 2010. Comparative cytomorphological studies on the studies of V. amygdalina Del. and V. kotschyama. Nigerian Journal of Botany 23(1):133–142.
  41. IGILE, G.O., W. OLEZEK, M. JURZYSATA, S. BURDA, M. FAFUNSO AND A.A. FASANMADE 1994. Flavonoids from Vernonia amygdalina and their antioxidant activities. J. Agric. and Food Chem. (USA) 42(11): 2445–2448.
  42. IJEH, I.I. AND C.E.C.C. EJIKE 2011. Current perspectives on the medicinal potentials of Vernonia amygdalina. Del. J. Med. Pl. Res. 5(7): 1051–1061.
  43. IJEH, I.I., V.O. NWUGO AND OBIDOA 1996. Comparative studies on the nutritive, phytochemical and antimicrobial properties of two varieties of Vernonia amygdalina. Plant Prod. Res. Comm. 1: 71–75.
  44. ILONDU, E.M. 2010. Phytochemical Composition and Efficacy of Ethanolic Leaf Extracts of Some Vernonia Species against Two Phytopathogenic Fungi. J. Biopest. 6(2): 165–172.
  45. IWALOKUN, B.A., B.U. EFEDEDE, J.A. ALABI-SOFUNDE, T. ODUALA, O.A. MAGBAGBEOLA AND A.I. AKINWANDE 2006. Hepatoprotective and Antioxidant Activities of Vernonia amygdalina on Acetaminophen-induced Hepatic Damage in Mice. J. Med. Food. 9(4): 524–30.
  46. IZEVBIGIE, E.B. 2003. Discovery of water-soluble anticancer agents (edotides) from a vegetable found in Benin City, Nigeria. Exp. Biol. Med. 228: 293–298.
  47. IZEVBIGIE, E.B., J.L. BRYANT AND A. WALKER 2004. A novel natural inhibitor of extracellular signal-regulated kinases and human breast cancer cell growth. Exp. Biol. Med. 229:163–169.
  48. JENNIFER, M., A.R. NUR ZAHIRAH AND K. HUSAIN 2020. A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases. Front. Pharmacol. 11: 852.
  49. JIAMIN, S.H.I., C. QIANQIAN, XU MENG, XIA QING, ZHENG TIANSHENG, JUNLIANG TENG, LI MING AND FAN LIHONG 2019. Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review. Cancer Med 8(6): 3004–3011.
  50. JISAKA, M., H. OHIGASHI, T. TAKAGAKI, H. NOZAKI, T. TADA, M. HIROTA, R. IRIE, M.A. HUFFMAN, T. NISHIDA, M. KAJI AND K. KOSHIMIZU 1992. Bitter steroids glucosides, vernoniosides A, A, and A and related B from a possible medicinal plant, Vernonia amygdalina used by wild chimpanzees. Tetrahedron 48: 625–632.
  51. JISAKA, M., H. OHIGASHI, K. TAKEGAWA, M. HIROTA, R. IRIE, M.A. HUFFMAN AND K. KOSHIMIZU 1993. Steroid glucosides from Vernonia amygdalina, a possible chimpanzee plant. Phytochemistry 34: 409–413.
  52. JUENGEL, E., A. THOMAS, J. RUTZ, J. MAKAREVIC, I. TSAUR, & AL., 2016. Amygdalin inhibits the growth of renal cell carcinoma cells in vitro. Int. J. Mol. Med. 37(2): 526–532.
  53. KAMATENESI-MUGISHA, M. 2004. Medicinal Plants used in Reproductive Health care in Western Uganda: Documentation, Phytochemical and Bioactivity Evaluation. Ph.D. Thesis in Botany, Makerere University, Kampala.
  54. KHALAFALLA, M.M., E. ABDELLATEF, H.M. DAFFALLA, A.A. NASSRALLAH, D.A. LIGHTFOOT, A. COCCHETTO AND H.A. EL-SHEMY 2009. Antileukemia Activity from Root Cultures of Vernonia amygdalina. J. Med. Plant Res. 3(8): 556–562.
  55. KHALAFALLA, M.M., E.I. ELAGAALI AND M.M. AHMED 2007. In vitro multiple shoot regeneration from nodal explants of Vernonia amygdalina- an important medicinal plant. African Crop Sci. Conf. Proc. 8: 747–752.
  56. KIPLIMO, J.J., N.A. KOORBANALLY AND H. CHENIA 2011. Triterpenoids from Vernonia auriculifera Hiern Exhibit Antimicrobial Activity. Afr. J. Pharm. Pharmacol. 5(8): 1150–1156.
  57. KOKWARO, J.O. 2009. Medicinal plants of East Africa 3rd ed. University of Nairobi Press. East Africa.
  58. KUMAR, S. AND S.K. VERMA 2012. An interesting medicinal plant from eastern Bihar: a new record for India. J. Econ. Taxon. Bot. 36(1): 86–89.
  59. KUPCHAN, S.M., R.J. HEMMNIGWAY, A. KARIM AND D. WERNER 1969. Tumor inhibitors. XLVII Vernodalin and Vernomygdin. Two new cytotoxic sesquiterpene lactones from Vernonia amygdalina Del. J. Org. Chem. 34: 3908–3911.
  60. LANG, X.X., X.E. YANG, W.Z. NI, Z.Q. YE, Z. HE, D.V. CALVERT AND J.P. STOFFELLA 2003. Assessing zinc thresholds for phytotoxicity and potential dietary toxicity in selected vegetable crops. Common Soil Science and Plant Anatomy 34: 1421–1434.
  61. LEE H.M. AND A. MOON 2016. Amygdalin regulates apoptosis and adhesion in Hs578T triple negative breast cancer cells. Biomol. Ther. (Seoul) 24(1): 62–66.
  62. LUO, X., Y. JIANG, F.R. FRONCZEK, C. LIN, E.B. IZEVBIGIE, L. LEE AND K.S. LEE 2017. Isolation and Structure Determination of a Sesquiterpene Lactone (Vernodalinol) from Vernonia amygdalina Extracts. Pharmaceutical Biology 49(5): 464–470.
  63. MAKAREVIC, J., J. RUTZ, E. JUENGEL AND S. KAULFU 2014. Amygdalin blocks bladder cancer cell growth in vitro by diminishing cyclin A and cdk2. PLoS ONE 9(8): e105590.
  64. MAKAREVIC, J., J. RUTZ, E. JUENGEL, S. KAULFUSS, I. TSAUR & AL., 2014. Amygdalin influences bladder cancer cell adhesion and invasion in vitro. PLoS ONE 9(10): e110244.
  65. MAKAREVIC, J., I. TSAUR, E. JUENGEL, H. BORGMANN, K. NELSON & AL., 2016. Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro. Life Sci. 147:137–142.
  66. MANSURAH, A.A., I. KASSIM, B. KENPIA AND B.B. HOPE 2013. Effect of Combined Use of Ocimum gratissimum and Vernonia amygdalina Extract on the Activity of Angiotensin Converting Enzyme, Hypolipidemic and Antioxidant Parameters in Streptozotocin induced Diabetic Rats. African Journal of Biochemistry Research 7(9): 165–173.
  67. MOUNDIPA, F.P., G. KAMINI, F. M ELANIE, F.C. BILONG AND I. BRUCHHAUS 2000. In vitro amoebic activity of some medicinal plants of the Bamun region (Cameroon) Afr. J. Tad. Cam. 62:113–121. MUNAYA, C. 2013. Bitter leaf-based extracts cures hepatitis co-inferation and others. The Guardian Newspaper, July 25.
  68. MURAINA, I.A., A.O. ADAUDI, M. MAMMAN, H.M. KAZEEM, J. PICARD, L.J. McGaw AND J.N. Eloff 2010. Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent. Pharm. Biol. 48: 1103–1107.
  69. MUSA, A., E.O. OGBADOYI, J.A. OLADIRAN, M.S. EZENWA AND H.O. AKANYA 2011. Effects of reproductive phase on some micronutrients, anti-nutrients and toxic substances in V. amygdalina. African Journal of Plant Science 5(9): 525–530.
  70. NGATU, N.R., M.K. OKAJIMA, M. YOKOGAWA, R. HIROTA, M. TAKAISHI, M. EITOKU AND N. SUGANUMA 2012. Anti-Allergic Effects of Vernonia amygdalina Leaf Extracts in Hapten-Induced Atopic Dermatitis-Like Disease in Mice. Allergol. Int. 61(4): 597–607.
  71. NJAN, A.A., B. ADZU, A.G. AGABA, D. BYARUGABA, S. DÍAZ-LLERA AND D.R. BANGSBERG 2008. The Analgesic and Antiplasmodial Activities and Toxicology of Vernonia amygdalina. J. Med. Food 11(3): 574–81.
  72. NWAOGUIKPE, R.N. 2010. The effect of extract of Bitter Leaf (Vernonia amygdalina) on Blood Glucose Levels of Diabetic Rats. Int. J. Biol. Chem. Sci. 4(3): 721–729.
  73. OKOLI, R.I., O. AIGBE, J.O. OHAFU-OBODE AND MENSAH 2007. Medicinal herbs used for managing some common ailments among Esan people Edo State, Nigeria. Pakistan Journal of Nutrition 6(5):470–490.
  74. OLAOFE, O. 1992. Vitamin C content of Nigerian foodstuffs. Nigerian Journal of Science 13(1&2): 1–7.
  75. OSHODI, A.A. 1992. Comparison of proteins, minerals and vitamin C content of some dried leafy vegetables. Pakistan Journal of Science and Industrial Research 35: 267–269.
  76. OWEN, O.J., A.O. AMAKIRI AND T.A. KARIBI-BOTOYE 2011. Sugar-Lowering Effects of Bitter Leaf (Vernonia amygdalina) in Experimental Broiler Finisher Chickens. Asian J. Pharm. Clin. Res. 4(1): 19–21.
  77. PARK, H.J., S.H. YOON, L.S. HAN, L.T. ZHENG, K.H. JUNG & AL., 2005. Amygdalin inhibits genes related to cell cycle in SNU‐C4 human colon cancer cells. World J. Gastroenterol 11(33): 5156–5161.
  78. QIAN, L., B. XIE, Y. WANG AND J. QIAN 2015. Amygdalin‐mediated inhibition of non‐small cell lung cancer cell invasion in vitro. Int. J. Clin. Exp. Pathol. 8(5): 5363–5370.
  79. QUASIE, O., Y. ZHANG, H. ZHANG, J. LUO AND L. KONG 2016. Four New Steroid Saponins with Highly Oxidized Side Chains from the Leaves of Vernonia amygdalina. Phytochemistry Letters 15: 16–20.
  80. REMISON, S.U. 2005. Arable and vegetable crops of the tropics. Gift- Print Associates, Benin-City.
  81. ROBINSON, H., S.C. KEELEY, J.J. SKVARLA AND R. CHAN 2008. Studies on the Gymnantheminae (Vernonieae: Asteraceae) III: restoration of the genus Strobocalyx and the new genus Tarlmounia. Proc. Biol. Soc. Washington 121: 19–33.
  82. ROBINSON, H., AND J.J. SKVARLA 2006. Studies on the Gymnantheminae (Vernonieae: Asteraceae): restoration of the genus Monosis. Proc. Biol. Soc. Washington 119: 600–607.
  83. ROBINSON, H. AND SKVARLA 2007. Studies on the Gymnantheminae (Asteraceae: Vernonieae). II: a new genus, Decaneuropis, from China, India, southeast Asia, and Malaysia. Proc. Biol. Soc. Washington 120: 360–366.
  84. ROBINSON, H. 1999a. Generic and subtribal classification of American Vernonieae. Smithsonian Contrib. Bot. 89: 1–116.
  85. ROBINSON, H. 1999b. Revisions in paleotropical Vernonieae (Asteraceae). Proc. Biol. Soc. Washington 112: 220–247.
  86. ROBINSON, H. 2007. Vernonieae. In: KADEREIT, J.W. AND C. JEFFREY (eds.) [Ser. Ed.: Kubitzki K], The Families and Genera of Vascular Plants, vol. VIII. Springer-Verlag, Berlin: 149–174.
  87. SCHIFFERS, R.R. 2000. African indigenous vegetables: an overview of the cultivated species. University Greenwich Press, England.
  88. SMITH, I.F. AND P. EYZAGUIRRE 2007. African leafy vegetables: their role in the world health organizations global fruit and vegetables initiative. African J. Food Agric. Nutri. and Develop. 7: 1–17.
  89. SODIMIC, A.L., O. ADEBAYO, N.O. OLADELE, O. AKINYEMI, O.O. ALABI, U.U. EMEGHARA AND S.A. OLUMUYIWA 2006. Comparative analysis of chemical composition in three species of bitter leaf (Vernonia spp). Journal of Research in Agriculture 3(3): 75–77.
  90. SOFOWORA, A. 1993. Medicinal plants and traditional medicine in Africa. Spectrum Books Ltd, Ibadan.
  91. SWAMY, J., G. PRABHAKAR, L. RASINGAM AND P. KAMALAKAR 2015. Gymnanthemum amygdalinum (Asteraceae)-A New Addition to the flora of Peninsular India. Int. J. Adv. Res. Sci. Technol 4(7): 449–451.
  92. TAPSELL 2006. Health benefits to herbs and spices: the past, the present and future. Medicinal Journal of Austria 1: 170–190.
  93. TOYANG, N.J. AND R. VERPOORTE 2013. A Review of the Medicinal Potentials of Plants of the Genus Vernonia (Asteraceae). J. Ethnopharmacol. 146(3): 681–723.
  94. UDOCHUKWU, U., F.I. OMEJE, I.S. ULOMA AND F.D. OSEIWE 2015. Phytochemical Analysis of Vernonia amygdalina and Ocimum gratissimum Extracts and their Antibacterial Activity on Some Drug Resistant Bacteria. American Journal of Research Communication 3(5): 225–235.
  95. WAALYENBERG, H. 1999. Vegetable garden in the tropics with special references to Africa. CTA/Agrodox Series Publication No 9. Pp 1–10.
  96. WONG, F.C., C.C. WOO, A. HSU AND B.K.H. TAN 2013. The Anti-Cancer Activities of Vernonia amygdalina Extract in Human Breast Cancer Cell Lines Are Mediated through Caspase-Dependent and p53-Independent Pathways. PLoS ONE 8(10): e78021. doi:10.1371/journal.pone.0078021.
  97. YEAP, S.K., H.O. WY, B.K. BEH, W.S. LIANG, H. KY, A. HADI, N. YOUSR AND N.B. ALITHEEN 2010. Vernonia amygdalina, an ethnoveterinary and ethno-medical used green vegetable with multiple bioactivities. J. Med. Pl. Research 4(25): 2787–2812.

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