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Volume 64, Issue 1, July 2022

Articles

Phytochemical Analysis and Anticancer Activity of Gracilaria tenuistipitata C.F.Chang & B.-M.xia against Breast Cancer MCF- 7 Cells

https://doi.org/10.20324/nelumbo/v64/2022/170155

Published 2022-08-03

  • S. Vivek
    • ,
  • Y. Aron Santhosh Kumar
    • ,
  • M. Palanisamy

S. Vivek
Botanical Survey of India, Southern Regional Centre, TNAU Campus, Coimbatore – 641 0031, Tamil Nadu

Y. Aron Santhosh Kumar
Botanical Survey of India, Southern Regional Centre, TNAU Campus, Coimbatore – 641 0031, Tamil Nadu

M. Palanisamy
Central National Herbarium, Botanical Survey of India, Botanic Garden, Howrah – 711 103

Abstract

The marine algae Gracilaria tenuistipitata was collected from the backwater area of the Kakinada coast, Andhra Pradesh, India. The main objective of this study is to determine the preliminary phytochemicals and anti-cancer activity of red seaweed. The anticancer activity was examined in ethyl acetate extract using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay against the breast cancer cell line (MCF-7). Seven compounds were identified in the ethylacetate extract of G. tenuistipitata and the major components were Oleic Acid, Phytol, and Squalene, which were found to have antimicrobial, antioxidant, anti -inflammatory, antitumor, and cancer preventive properties. The results of this research indicated that the ethylacetate extract of G. tenuistipitata could be the source for anti-cancerous potential against breast cancer cells.

Keywords

Red Seaweed, Phytochemical, GC-MS, Cytotoxicity.

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